The group takes a broad interdisciplinary approach to research, with an underpinning focus on the development of modular sensors where we have pioneered a range of reporting regimes. Research interests include many aspects of Supramolecular chemistry, including: Molecular Recognition, Fluorescence Sensor design, Fluorescence Imaging, Theranostics, Chiral recognition; Saccharide recognition, Anion recognition and Sensors for Reactive Oxygen Species (ROS).
The ability to monitor analytes within physiological, environmental and industrial scenarios is of prime importance. Since recognition events occur on a molecular level, gathering and processing the information poses a fundamental challenge. Therefore robust chemical molecular sensors “chemosensors” with the capacity to detect chosen molecules selectively and signal this presence continue to attract considerable attention. Real-time monitoring of saccharides is of particular interest, such as D-glucose in blood. Towards that end the covalent coupling interaction between boronic acids and saccharides has been exploited with some success to monitor the presence of such saccharides. The boronic acid Lewis acid-base interaction is also suitable for the capture and recognition of anions. Anions are involved in fundamental processes in all living things. Our aim is to mimic nature’s level of sophistication in designing and producing chemosensors capable of determining the concentration of a target species such as: saccharides, glycated proteins, anions and reactive oxygen/nitrogen species (ROS/RNS) in any medium.